Total synthesis of (+/-)-welwitindolinone a isonitrile.
نویسندگان
چکیده
A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol.
منابع مشابه
A mild and efficient synthesis of oxindoles: progress towards the synthesis of welwitindolinone A isonitrile.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 5 شماره
صفحات -
تاریخ انتشار 2006